NPTX2 anticorps (Secreted)

N° du produit ABIN7581924

Cet anticorps anti-NPTX2 est un anticorps Lapin Polyclonal détectant NPTX2 dans WB et IHC. Adapté pour Souris.

Aperçu rapide pour NPTX2 anticorps (Secreted) (ABIN7581924)

Antigène: NPTX2 (Neuronal Pentraxin II (NPTX2))

Reactivité: Souris

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Cet anticorp NPTX2 est non-conjugé

Application: Western Blotting (WB), Immunohistochemistry (IHC)

Détail du produit anti-NPTX2 anticorps

Épitope: AA 186-198, Secreted

Fonction: A Rabbit Polyclonal antibody to Neuronal Pentraxin 2 (NPTX2)

Séquence: (C)HNETSAHRQK TES

Specificité: Secreted

Homologie: Human - identical,rat - 12 out of 13 amino acid residues identical

Attributs du produit: Anti-Neuronal Pentraxin 2 (NPTX2) Antibody (ABIN7581924) is a highly specific antibody directed against an epitope of the mouse protein. The antibody can be used in western blot and immunohistochemistry applications. It has been designed to recognize NPTX2 from rat, mouse and human samples.

Purification: Affinity purified on immobilized antigen.

Immunogène: (C)HNETSAHRQKTES, corresponding to amino acid residues 186 - 198 of mouse NPTX2 

Isotype: IgG

Information d'application

Indications d'application:

Antigen preadsorption control: 1 μg peptide per 1 μg antibody

Application Dilutions Immunohistochemistry paraffin embedded sections ihc: 1:300

Application Dilutions Western blot wb: 1:200

Restrictions: For Research Use only

Stockage

Format: Lyophilized

Reconstitution: 0.2 mL double distilled water (DDW).

Concentration: 1 mg/mL

Buffer: PBS pH 7.4

Stock: 4 °C,-20 °C

Stockage commentaire:

Storage before reconstitution: The antibody ships as a lyophilized powder at room temperature. Upon arrival, it should be stored at -20°C.

Storage after reconstitution: The reconstituted solution can be stored at 4°C for up to 1 week. For longer periods, small aliquots should be stored at -20°C. Avoid multiple freezing and thawing. Centrifuge all antibody preparations before use (10000 x g 5 min).

Détails sur NPTX2

Antigène: NPTX2 (Neuronal Pentraxin II (NPTX2))

Autre désignation: NPTX2

Sujet: Neuronal Pentraxin-2, NP2, Neuronal Activity-Regulated Pentaxin, NARP,Neuronal pentraxin 2 (NP2), also known as NPTX2, NP-II, and neuronal activity-regulated pentraxin (Narp), is a calcium-dependent lectin secreted protein member of the pentraxin family involved in synaptic plasticity and excitatory homeostasis.1,2NP2 is part of the neuronal pentraxin family that includes two other members: Neuronal Pentraxin 1 (NP1) and Neuronal Pentraxin Receptor (NPTXR). The pentraxin superfamily members are arranged in pentameric structures with a discoid shape. The family members are characterized by a 205 amino acids long conserved sequence located at C-terminal called the pentraxin domain 2,3.NP2 is widely expressed in the brain, especially in the hippocampus, dentate gyrus, cerebellum, and cerebral cortex regions, as well as in the testis, pancreas, liver, heart, and skeletal muscle.2,3NP2 interacts with α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, which are crucial for excitatory neurotransmission in the brain. By binding to AMPA receptors, NP2 influences their trafficking and localization at synapses, affecting the strength of excitatory synaptic transmission 2,3.Given its presence in brain regions associated with learning and memory, alterations in NP2 levels or function have been implicated in cognitive processes. Dysregulation of NP2 has been observed in various neurological disorders, suggesting its potential importance in maintaining cognitive function.4-6Abnormalities in NP2 expression have been linked to neurodegenerative disorders, including Alzheimer's disease. Changes in NP2 levels may contribute to synaptic dysfunction and cognitive decline observed in these conditions.4-6

ID gène: 53324

UniProt: O70340